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Andropel finasteride 1 mg precio (L'Oreal, Paris; P.J. Auchterlonie, France) was rubbed over the entire facial area, avoiding chin and temples, applied for 20 min. Participants were asked to refrain from food or alcohol for 24 h before the study session and, for 5 days, they were allowed to drink only tap water. To prevent any possible alterations of blood vessel function in facial tissues caused by the use of an antiandrogen, participants consumed a control drink containing 50 mg of propofol. They were then divided into 3 groups by age in the following order of increasing daily doses finasteride: 15, 25, or 40 mg. At the end of 21 day trial, participants were asked their subjective perception of the severity facial lines and hyperpigmentation, as presented below, each with subjective evaluations of 1 point on a 9-point scale.[3] The intensity ratings were measured from 0 (unimaginable and incomprehensible) to 9 (severe devastating) with a 9-point scale.[3] Overall score Finasteride 15 mg or 40 significantly reduced the severity of facial appearance changes line and hyperpigmentation, with a mean difference of 6.1 (P = 0.03) points. Face appearance (dark circles and dark spots) Finasteride 15 mg significantly reduced the severity of dark circles and spots the forehead to a greater extent (6.8 points; P = 0.02) than finasteride 40 mg/day, with no significant difference between finasteride 15 and 40 mg. Glands on the cheeks Narrowing of the lower lip was significantly reduced (6.6 points; P = 0.02) in the group receiving 15 mg/day, whereas the area that was lightened not statistically significant. In the other 2 groups, no changes were noted. Glands on the forehead Tunnel vision (darkened eyes and forehead areas) was decreased significantly (6 points; P = 0.02) in the group receiving 15 mg/day, which contrasted with a no effect in the other 2 groups. Concentration of melanin on the face and upper eyelids The number of melanocytes in skin the outer facial was significantly increased with finasteride compared the control group at start of the 21 day trial (8.2 points, P = 0.001). Skin temperature The mean skin temperature was significantly reduced (0.08 celsius) with finasteride compared the control group (0.1 Celsius), which contrasted with a significant increase (6.4 points, P = 0.003) in the other 2 groups. Melanin production and distribution In the facial areas that are affected by acne, more melanin was removed when the dosage increased to 30 mg/day than in the areas that were not affected such as in the mouth, on nose. Stroke risk The effect of finasteride on stroke risk was evaluated in a pooled analysis of all studies that investigated its pharmacokinetics, pharmacodynamics, and safety, it was evaluated as a proportion of the incidence stroke with a rate of 0.5%. There were no cases of stroke in the control group most of studies where the participants had used 10 mg/day from the beginning.[22] As the dose was increased, stroke risk reduced. For each 10 mg/day increase seen in the dose, stroke.

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